Objective: To determine if the available data suport the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders.
The proposition that insufficinet nutrient intake can influence brain function and clinical psychiatric satates is not novel. For example, deficiencies in vitamin B12, thiamine, niacin and folate are known to have adverse neuropsychiatric effects.
General health benefits are associated with omega-3 EFA such as cardiovascular benefits. Data suggest a role of omega-3 EFA in the prevention and treatment of gastrointestinal, rheumatologic, bone and respiratory illnesses. Omnega-3 EFA consumption may decrease the risk of breast, prostate and lung cancer.
Several studies have shown that adding omega-3 in the diet has a positive effect on bipolar patients and in patients with schizophrenia compared with placebo patients.
The relationship between development of demnetia and fatty acid intake was examined in the Rotterdam Study.
Epidemiologic studies have yielded inconsistent findings about omega-3EFA intake and risk of dementia. Subjects who consumed fish at least weekly had a 60% lower risk of Alzheimer's disease compared with those who never or rarely ate fish, after adjustment for age and other risk factor.
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